{"id":2777,"date":"2021-01-28T09:08:23","date_gmt":"2021-01-28T09:08:23","guid":{"rendered":"https:\/\/www.reseau-amylose.org\/jesuissoignant\/?page_id=2777"},"modified":"2026-08-25T18:31:18","modified_gmt":"2026-08-25T16:31:18","slug":"evaluation-du-pronostic-des-amyloses-les-scores","status":"publish","type":"page","link":"https:\/\/reseau-amylose.org\/jesuissoignant\/evaluation-du-pronostic-des-amyloses-les-scores\/","title":{"rendered":"Evaluation du pronostic des amyloses : les scores"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"2777\" class=\"elementor elementor-2777\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-be77b71 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"be77b71\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c8c7d97\" data-id=\"c8c7d97\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d665792 elementor-widget elementor-widget-heading\" data-id=\"d665792\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Evaluation du pronostic des amyloses : les scores<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4004d9b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4004d9b\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-43d07ac\" data-id=\"43d07ac\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8647982 elementor-widget elementor-widget-text-editor\" data-id=\"8647982\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em>Les scores pronostiques des amyloses estiment le pronostic du patient \u00e0 partir de biomarqueurs mesur\u00e9s avant traitement. Ils sont indicatifs et \u00e9voluent dans le temps. Des scores distincts existent pour l&rsquo;amylose AL et pour l&rsquo;amylose \u00e0 transthyr\u00e9tine (TTR).<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-237a532 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"237a532\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5d447e7\" data-id=\"5d447e7\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-49af2d3 elementor-widget elementor-widget-heading\" data-id=\"49af2d3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Points cl\u00e9s pour les professionnels de sant\u00e9<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5f112d4 elementor-widget elementor-widget-text-editor\" data-id=\"5f112d4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Les scores pronostiques sont indicatifs et calcul\u00e9s \u00e0 partir des valeurs basales, avant traitement.<\/li><li>Amylose AL : trois scores de r\u00e9f\u00e9rence (Mayo 2004, Mayo 2012, European 2015), combinant troponine, NT-proBNP\/BNP et parfois cha\u00eenes l\u00e9g\u00e8res libres (dFLC).<\/li><li>Amylose TTR : score Mayo TTR (troponine + NT-proBNP) et score NAC (eGFR + NT-proBNP).<\/li><li>Un nouveau score (2025) est sp\u00e9cifiquement valid\u00e9 chez les patients ATTRv d\u00e9j\u00e0 sous traitement sp\u00e9cifique, combinant strain longitudinal global, NT-proBNP et fonction r\u00e9nale, avec des survies \u00e0 5 ans tr\u00e8s contrast\u00e9es selon le stade (98,5 % en stade I contre 29,4 % en stade III).<\/li><li>La correspondance entre techniques de dosage (troponine, cha\u00eenes l\u00e9g\u00e8res) doit \u00eatre v\u00e9rifi\u00e9e avant d&rsquo;appliquer un seuil, les techniques n&rsquo;\u00e9tant pas toutes \u00e9quivalentes.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d7be9d2 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d7be9d2\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8bdebd1\" data-id=\"8bdebd1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-91912e9 elementor-widget elementor-widget-heading\" data-id=\"91912e9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Les scores pour l'amylose AL, en fonction des biomarqueurs<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c58b0fb elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c58b0fb\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2c2d175\" data-id=\"2c2d175\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f53a6b1 elementor-widget elementor-widget-text-editor\" data-id=\"f53a6b1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Le score est d\u00e9fini par rapport aux valeurs basales avant la mise en route de la chimioth\u00e9rapie. Plusieurs types de marqueurs cardiaques peuvent \u00eatre utilis\u00e9s (NT-proBNP ou BNP ; troponine T, I ou T ultrasensible) ; la correspondance entre techniques suit la publication de Muchtar et al. (Blood, 2019). Les mesures de cha\u00eenes l\u00e9g\u00e8res sont, dans la plupart des publications, issues de la technique Freelite (Binding Site) ; la correspondance avec d&rsquo;autres techniques (ex. Siemens) n&rsquo;est pas connue.<\/p><p><strong>Score Mayo 2004<\/strong><\/p><table width=\"623\"><tbody><tr><td width=\"80\"><p><strong>Stade<\/strong><\/p><\/td><td width=\"200\"><p><strong>Troponine (cTnT \u22650,035 mg\/l ou HS-cTnT \u226550 ng\/l)<\/strong><\/p><\/td><td width=\"187\"><p><strong>NT-proBNP \u2265332 pg\/ml ou BNP &gt;81 ng\/l<\/strong><\/p><\/td><td width=\"157\"><p><strong>HR d\u00e9c\u00e8s (IC 95%)<\/strong><\/p><\/td><\/tr><tr><td width=\"80\"><p>I<\/p><\/td><td width=\"200\"><p>0<\/p><\/td><td width=\"187\"><p>0<\/p><\/td><td width=\"157\"><p>R\u00e9f\u00e9rence<\/p><\/td><\/tr><tr><td width=\"80\"><p>II<\/p><\/td><td width=\"200\"><p>1 des 2 crit\u00e8res<\/p><\/td><td width=\"187\"><p>\u00a0<\/p><\/td><td width=\"157\"><p>2,5 (1,9\u20133,5)<\/p><\/td><\/tr><tr><td width=\"80\"><p>III<\/p><\/td><td width=\"200\"><p>1<\/p><\/td><td width=\"187\"><p>1<\/p><\/td><td width=\"157\"><p>6,7 (5,0\u20139,1)<\/p><\/td><\/tr><\/tbody><\/table><p><em>R\u00e9f\u00e9rence : Dispenzieri A, Gertz MA, Kyle RA et al. J Clin Oncol. 2004.<\/em><\/p><p><strong>Score Mayo 2012<\/strong><\/p><table width=\"623\"><tbody><tr><td width=\"60\"><p><strong>Stade<\/strong><\/p><\/td><td width=\"173\"><p><strong>Troponine (cTnT \u22650,025 ng\/ml ou HS-cTnT \u226540 ng\/l)<\/strong><\/p><\/td><td width=\"133\"><p><strong>NT-proBNP \u22651800 pg\/ml<\/strong><\/p><\/td><td width=\"133\"><p><strong>dFLC \u226518 mg\/dl (180 mg\/l)<\/strong><\/p><\/td><td width=\"123\"><p><strong>HR d\u00e9c\u00e8s (IC 95%)<\/strong><\/p><\/td><\/tr><tr><td width=\"60\"><p>I<\/p><\/td><td width=\"173\"><p>0<\/p><\/td><td width=\"133\"><p>0<\/p><\/td><td width=\"133\"><p>0<\/p><\/td><td width=\"123\"><p>R\u00e9f\u00e9rence<\/p><\/td><\/tr><tr><td width=\"60\"><p>II<\/p><\/td><td width=\"173\"><p>1 crit\u00e8re augment\u00e9<\/p><\/td><td width=\"133\"><p>\u00a0<\/p><\/td><td width=\"133\"><p>\u00a0<\/p><\/td><td width=\"123\"><p>1,7 (1,2\u20132,3)<\/p><\/td><\/tr><tr><td width=\"60\"><p>III<\/p><\/td><td width=\"173\"><p>2 crit\u00e8res augment\u00e9s<\/p><\/td><td width=\"133\"><p>\u00a0<\/p><\/td><td width=\"133\"><p>\u00a0<\/p><\/td><td width=\"123\"><p>4,1 (3,1\u20135,5)<\/p><\/td><\/tr><tr><td width=\"60\"><p>IV<\/p><\/td><td width=\"173\"><p>1<\/p><\/td><td width=\"133\"><p>1<\/p><\/td><td width=\"133\"><p>1<\/p><\/td><td width=\"123\"><p>6,3 (4,8\u20138,3)<\/p><\/td><\/tr><\/tbody><\/table><p><em>R\u00e9f\u00e9rence : Kumar S, Dispenzieri A, Lacy MQ et al. J Clin Oncol. 2012.<\/em><\/p><p><strong>Score European 2015<\/strong><\/p><table width=\"623\"><tbody><tr><td width=\"80\"><p><strong>Stade<\/strong><\/p><\/td><td width=\"200\"><p><strong>Troponine (cTnT \u22650,035 ng\/ml ou HS-cTnT \u226550 ng\/l)<\/strong><\/p><\/td><td width=\"213\"><p><strong>NT-proBNP \u2265332 pg\/ml ou BNP &gt;81 ng\/l<\/strong><\/p><\/td><td width=\"130\"><p><strong>HR d\u00e9c\u00e8s (IC 95%)<\/strong><\/p><\/td><\/tr><tr><td width=\"80\"><p>I<\/p><\/td><td width=\"200\"><p>0<\/p><\/td><td width=\"213\"><p>0<\/p><\/td><td width=\"130\"><p>R\u00e9f\u00e9rence<\/p><\/td><\/tr><tr><td width=\"80\"><p>II<\/p><\/td><td width=\"200\"><p>1 des 2<\/p><\/td><td width=\"213\"><p>\u00a0<\/p><\/td><td width=\"130\"><p>2,6 (1,9\u20133,5)<\/p><\/td><\/tr><tr><td width=\"80\"><p>III-a<\/p><\/td><td width=\"200\"><p>1<\/p><\/td><td width=\"213\"><p>1 (NT-proBNP &lt;8500 \/ BNP &lt;700)<\/p><\/td><td width=\"130\"><p>4,9 (3,6\u20136,8)<\/p><\/td><\/tr><tr><td width=\"80\"><p>III-b<\/p><\/td><td width=\"200\"><p>1<\/p><\/td><td width=\"213\"><p>NT-proBNP &gt;8500 ou BNP &gt;700<\/p><\/td><td width=\"130\"><p>11,1 (8,1\u201315,4)<\/p><\/td><\/tr><\/tbody><\/table><p><em>R\u00e9f\u00e9rence : Palladini G, Sachchithanantham S, Milani P et al. Blood. 2015.<\/em><\/p><p>\u00a0<\/p><h5><strong>Lien pour pubmed des articles r\u00e9f\u00e9renc\u00e9s\u00a0: Scores Amylose AL<\/strong><\/h5><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30545829\/\"><em>Staging<\/em><em> systems use for risk stratification of systemic amyloidosis in the era of high-sensitivity troponin T assay. <\/em><\/a><\/p><p><em>Muchtar E<\/em><em>, Kumar SK, Gertz MA, Grogan M, AbouEzzeddine OF, Jaffe AS, Dispenzieri A. Blood. <\/em><em>2019 Feb 14;133(7):763-766. doi: 10.1182\/blood-2018-10-875252. Epub 2018 Dec 13. PMID: 30545829 <\/em><\/p><p><em>\u00a0<\/em><\/p><p><em>MAYO 2004\u00a0:<\/em> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15365071\/\"><em>Serum<\/em><em> cardiac troponins and N-terminal pro-brain natriuretic peptide: a staging system for primary systemic amyloidosis. <\/em><\/a><em>Dispenzieri A, Gertz MA, Kyle RA, Lacy MQ, Burritt MF, Therneau TM, Greipp PR, Witzig TE, Lust JA, Rajkumar SV, Fonseca R, Zeldenrust SR, McGregor CG, Jaffe AS. <\/em><em>J Clin Oncol. 2004 Sep 15;22(18):3751-7. doi: 10.1200\/JCO.2004.03.029. PMID: 15365071 <\/em><\/p><p><em>EUROPEAN 2015\u00a0: <\/em><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25987656\/\"><em>A European collaborative study of cyclophosphamide, bortezomib, and dexamethasone in upfront treatment of systemic AL amyloidosis. <\/em><\/a><em>Palladini G<\/em><em>, Sachchithanantham S, Milani P, Gillmore J, Foli A, Lachmann H, Basset M, Hawkins P, Merlini G, Wechalekar AD. Blood. 2015 Jul 30;126(5):612-5. doi: 10.1182\/blood-2015-01-620302. Epub 2015 May 18. PMID: 25987656 <\/em><\/p><p><em>\u00a0<\/em><\/p><p><em>MAYO 2012\u00a0: <\/em><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22331953\/\"><em>Revised prognostic staging system for light chain amyloidosis incorporating cardiac biomarkers and serum free light chain measurements. <\/em><\/a><em>Kumar S<\/em><em>, Dispenzieri A, Lacy MQ, Hayman SR, Buadi FK, Colby C, Laumann K, Zeldenrust SR, Leung N, Dingli D, Greipp PR, Lust JA, Russell SJ, Kyle RA, Rajkumar SV, Gertz MA. <\/em><em>J Clin Oncol. 2012 Mar 20;30(9):989-95. doi: 10.1200\/JCO.2011.38.5724. Epub 2012 Feb 13. PMID: 22331953 <\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-027b168 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"027b168\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-24d15ae\" data-id=\"24d15ae\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-1b17112\" data-id=\"1b17112\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7bb2dab elementor-widget elementor-widget-image\" data-id=\"7bb2dab\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"http:\/\/reseau-amylose.org\/jesuissoignant\/wp-content\/uploads\/sites\/5\/2024\/04\/PLAQUETTE-Pronostic-AL-sans-mediane-de-survie-1.pdf\" target=\"_blank\">\n\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"769\" src=\"https:\/\/reseau-amylose.org\/jesuissoignant\/wp-content\/uploads\/sites\/5\/2024\/04\/evaluation-Pronostic-amyloses-AL-scores-copie.jpg\" class=\"attachment-large size-large wp-image-6459\" alt=\"\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-5a46471\" data-id=\"5a46471\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d55848d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d55848d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-dbcc53e\" data-id=\"dbcc53e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-04cf8a5 elementor-cta--skin-cover elementor-animated-content elementor-bg-transform elementor-bg-transform-zoom-in elementor-widget elementor-widget-call-to-action\" data-id=\"04cf8a5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"call-to-action.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<a class=\"elementor-cta\" href=\"http:\/\/reseau-amylose.org\/jesuissoignant\/wp-content\/uploads\/sites\/5\/2024\/04\/Scores-Pronostiques-des-Amyloses-AL-pour-site-web-1.pdf\" target=\"_blank\">\n\t\t\t\t\t<div class=\"elementor-cta__bg-wrapper\">\n\t\t\t\t<div class=\"elementor-cta__bg elementor-bg\" style=\"background-image: url(https:\/\/reseau-amylose.org\/jesuissoignant\/wp-content\/uploads\/sites\/5\/2021\/01\/Capture-de\u0301cran-2021-01-28-a\u0300-10.13.21-1024x649.png);\" role=\"img\" aria-label=\"Capture d\u2019e\u0301cran 2021-01-28 a\u0300 10.13.21\"><\/div>\n\t\t\t\t<div class=\"elementor-cta__bg-overlay\"><\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-cta__content\">\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<h2 class=\"elementor-cta__title elementor-cta__content-item elementor-content-item elementor-animated-item--grow\">\n\t\t\t\t\t\tScores Pronostiques des Amyloses AL\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__button-wrapper elementor-cta__content-item elementor-content-item elementor-animated-item--grow\">\n\t\t\t\t\t<span class=\"elementor-cta__button elementor-button elementor-size-\">\n\t\t\t\t\t\tT\u00c9L\u00c9CHARGER LE DOCUMENT\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-f1cd35f\" data-id=\"f1cd35f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7c34736 elementor-cta--skin-cover elementor-animated-content elementor-bg-transform elementor-bg-transform-zoom-in elementor-widget elementor-widget-call-to-action\" data-id=\"7c34736\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"call-to-action.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<a class=\"elementor-cta\" href=\"http:\/\/reseau-amylose.org\/jesuissoignant\/wp-content\/uploads\/sites\/5\/2024\/04\/Scores-Pronostiques-des-Amyloses-TTR-pour-site-web.pdf\" target=\"_blank\">\n\t\t\t\t\t<div class=\"elementor-cta__bg-wrapper\">\n\t\t\t\t<div class=\"elementor-cta__bg elementor-bg\" style=\"background-image: url(https:\/\/reseau-amylose.org\/jesuissoignant\/wp-content\/uploads\/sites\/5\/2021\/01\/Capture-de\u0301cran-2021-01-28-a\u0300-10.19.39-1024x747.png);\" role=\"img\" aria-label=\"Capture d\u2019e\u0301cran 2021-01-28 a\u0300 10.19.39\"><\/div>\n\t\t\t\t<div class=\"elementor-cta__bg-overlay\"><\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-cta__content\">\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<h2 class=\"elementor-cta__title elementor-cta__content-item elementor-content-item elementor-animated-item--grow\">\n\t\t\t\t\t\tScores Pronostiques des Amyloses TTR\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__button-wrapper elementor-cta__content-item elementor-content-item elementor-animated-item--grow\">\n\t\t\t\t\t<span class=\"elementor-cta__button elementor-button elementor-size-\">\n\t\t\t\t\t\tT\u00c9L\u00c9CHARGER LE DOCUMENT\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-633b83d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"633b83d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7eddace\" data-id=\"7eddace\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c49582e elementor-widget elementor-widget-heading\" data-id=\"c49582e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Scores pronostiques des amyloses \u00e0 transthyr\u00e9tine (ATTRwt et ATTRv)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-04450e3 elementor-widget elementor-widget-text-editor\" data-id=\"04450e3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>\u00a0<\/strong>Ces scores sont eux aussi indicatifs et \u00e9voluent dans le temps. La correspondance des seuils entre techniques de troponine suit la m\u00eame publication de r\u00e9f\u00e9rence (Muchtar et al., Blood 2019).<\/p><p><strong>Score Mayo TTR<\/strong><\/p><table width=\"623\"><tbody><tr><td width=\"80\"><p><strong>Stade<\/strong><\/p><\/td><td width=\"200\"><p><strong>Troponine (cTnT &gt;0,05 ou HS-cTnT \u226565 ng\/l)<\/strong><\/p><\/td><td width=\"147\"><p><strong>NT-proBNP &gt;3000<\/strong><\/p><\/td><td width=\"197\"><p><strong>HR d\u00e9c\u00e8s (IC 95%)<\/strong><\/p><\/td><\/tr><tr><td width=\"80\"><p>I<\/p><\/td><td width=\"200\"><p>0<\/p><\/td><td width=\"147\"><p>0<\/p><\/td><td width=\"197\"><p>R\u00e9f\u00e9rence<\/p><\/td><\/tr><tr><td width=\"80\"><p>II<\/p><\/td><td width=\"200\"><p>1 des 2<\/p><\/td><td width=\"147\"><p>\u00a0<\/p><\/td><td width=\"197\"><p>1,4 (0,8\u20132,6)<\/p><\/td><\/tr><tr><td width=\"80\"><p>III<\/p><\/td><td width=\"200\"><p>1<\/p><\/td><td width=\"147\"><p>1<\/p><\/td><td width=\"197\"><p>3,6 (2,0\u20136,4)<\/p><\/td><\/tr><\/tbody><\/table><p><em>R\u00e9f\u00e9rence : Grogan M, Scott CG, Kyle RA et al. JACC. 2016.<\/em><\/p><p><strong>Score NAC<\/strong><\/p><table width=\"623\"><tbody><tr><td width=\"80\"><p><strong>Stade<\/strong><\/p><\/td><td width=\"200\"><p><strong>eGFR &lt;45 mL\/min\/1,73m\u00b2<\/strong><\/p><\/td><td width=\"147\"><p><strong>NT-proBNP &gt;3000<\/strong><\/p><\/td><td width=\"197\"><p><strong>HR d\u00e9c\u00e8s (IC 95%)<\/strong><\/p><\/td><\/tr><tr><td width=\"80\"><p>I<\/p><\/td><td width=\"200\"><p>0<\/p><\/td><td width=\"147\"><p>0<\/p><\/td><td width=\"197\"><p>R\u00e9f\u00e9rence<\/p><\/td><\/tr><tr><td width=\"80\"><p>II<\/p><\/td><td width=\"200\"><p>1 des 2<\/p><\/td><td width=\"147\"><p>\u00a0<\/p><\/td><td width=\"197\"><p>2,1 (1,5\u20132,8)<\/p><\/td><\/tr><tr><td width=\"80\"><p>III<\/p><\/td><td width=\"200\"><p>1<\/p><\/td><td width=\"147\"><p>1<\/p><\/td><td width=\"197\"><p>3,8 (2,7\u20135,3)<\/p><\/td><\/tr><\/tbody><\/table><p><em>R\u00e9f\u00e9rence : Gillmore JD, Damy T, Fontana M et al. Eur Heart J. 2018.<\/em><\/p><p>\u00a0<\/p><p><em>\u00a0<\/em><\/p><p><em>\u00a0<\/em><\/p><h5><strong>Lien pour pubmed des articles r\u00e9f\u00e9renc\u00e9s\u00a0: Scores Amyloses TTR<\/strong><\/h5><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30545829\/\"><em>Staging<\/em><em> systems use for risk stratification of systemic amyloidosis in the era of high-sensitivity troponin T assay. <\/em><\/a><\/p><p><em>Muchtar E<\/em><em>, Kumar SK, Gertz MA, Grogan M, AbouEzzeddine OF, Jaffe AS, Dispenzieri A. Blood. <\/em><em>2019 Feb 14;133(7):763-766. doi: 10.1182\/blood-2018-10-875252. Epub 2018 Dec 13. PMID: 30545829 <\/em><\/p><p><em>Haut du formulaire<\/em><\/p><p><em>Bas du formulaire<\/em><\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27585505\/\"><em>Natural History of Wild-Type Transthyretin\u00a0Cardiac Amyloidosis and\u00a0Risk Stratification Using a Novel\u00a0Staging System. <\/em><\/a><\/p><p><em>Grogan M<\/em><em>, Scott CG, Kyle RA, Zeldenrust SR, Gertz MA, Lin G, Klarich KW, Miller WL, Maleszewski JJ, Dispenzieri A. J Am Coll Cardiol. 2016 Sep 6;68(10):1014-20. doi: 10.1016\/j.jacc.2016.06.033.<\/em><\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29048471\/\"><em>A new staging system for cardiac transthyretin amyloidosis. <\/em><\/a><\/p><p><em>Gillmore JD<\/em><em>, Damy T, Fontana M, Hutchinson M, Lachmann HJ, Martinez-Naharro A, Quarta CC, Rezk T, Whelan CJ, Gonzalez-Lopez E, Lane T, Gilbertson JA, Rowczenio D, Petrie A, Hawkins PN. <\/em><em>Eur Heart J. 2018 Aug 7;39(30):2799-2806. doi: 10.1093\/eurheartj\/ehx589.<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-befc63d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"befc63d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-960ff8c\" data-id=\"960ff8c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e30f02d elementor-widget elementor-widget-heading\" data-id=\"e30f02d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Nouveau score pour l'amylose h\u00e9r\u00e9ditaire \u00e0 transthyr\u00e9tine sous traitement sp\u00e9cifique<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9139da9 elementor-widget elementor-widget-text-editor\" data-id=\"9139da9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Un nouveau score a \u00e9t\u00e9 d\u00e9velopp\u00e9 sur une population de patients atteints d&rsquo;amylose h\u00e9r\u00e9ditaire \u00e0 transthyr\u00e9tine (ATTRv) d\u00e9j\u00e0 trait\u00e9s par th\u00e9rapies sp\u00e9cifiques (dont le tafamidis), reposant sur trois crit\u00e8res :<\/p><ul><li>Strain global longitudinal (GLS) \u2265 -11 %<\/li><li>NT-proBNP \u2265 2000 ng\/l<\/li><li>eGFR \u2264 65 mL\/min<\/li><\/ul><p>Trois stades pronostiques sont distingu\u00e9s, avec des survies \u00e0 5 ans tr\u00e8s diff\u00e9rentes :<\/p><ul><li>Stade I : aucun crit\u00e8re pr\u00e9sent \u2014 survie \u2248 98,5 %<\/li><li>Stade II : un crit\u00e8re pr\u00e9sent \u2014 survie \u2248 75,1 %<\/li><li>Stade III : GLS \u2265 -11 % associ\u00e9 \u00e0 au moins un autre crit\u00e8re \u2014 survie \u2248 29,4 %<\/li><\/ul><p>\u00a0<\/p><table width=\"623\"><tbody><tr><td width=\"60\"><p><strong>Stade<\/strong><\/p><\/td><td width=\"220\"><p><strong>GLS \u2265 -11 %<\/strong><\/p><\/td><td width=\"133\"><p><strong>NT-proBNP \u22652000<\/strong><\/p><\/td><td width=\"110\"><p><strong>eGFR \u226465 mL\/min<\/strong><\/p><\/td><td width=\"100\"><p><strong>HR d\u00e9c\u00e8s (IC 95%)<\/strong><\/p><\/td><\/tr><tr><td width=\"60\"><p>I<\/p><\/td><td width=\"220\"><p>0<\/p><\/td><td width=\"133\"><p>et 0<\/p><\/td><td width=\"110\"><p>et 0<\/p><\/td><td width=\"100\"><p>R\u00e9f\u00e9rence<\/p><\/td><\/tr><tr><td width=\"60\"><p>II<\/p><\/td><td width=\"220\"><p>1 seul crit\u00e8re parmi les 3<\/p><\/td><td width=\"133\"><p>\u00a0<\/p><\/td><td width=\"110\"><p>\u00a0<\/p><\/td><td width=\"100\"><p>13,47 (1,79\u2013101,67)<\/p><\/td><\/tr><tr><td width=\"60\"><p>III<\/p><\/td><td width=\"220\"><p>1<\/p><\/td><td width=\"133\"><p>et au moins 1 des 2 autres<\/p><\/td><td width=\"110\"><p>\u00a0<\/p><\/td><td width=\"100\"><p>54,3 (7,45\u2013396,04)<\/p><\/td><\/tr><\/tbody><\/table><p><em>R\u00e9f\u00e9rence : Neculae G, Zaroui A, Adam R, Kharoubi M, Funalot B, Coriu D, Jurcut R, Damy T. A new staging system for hereditary transthyretin amyloidosis in the era of specific amyloidosis therapies. ESC Heart Failure. 2025. PMID : 40903446 \u2014\u00a0<\/em><a href=\"https:\/\/reseau-amylose.org\/jesuissoignant\/wp-content\/uploads\/sites\/5\/2025\/11\/Amyloidosis-PROGNOSIS-New-Prognostic-Staging-Neculae-ESC-HF-2025.pdf\">lien vers l&rsquo;article<\/a><\/p><p>\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-bd9f94a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bd9f94a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f79db5c\" data-id=\"f79db5c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8942d6f elementor-widget elementor-widget-image\" data-id=\"8942d6f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1024\" height=\"456\" src=\"https:\/\/reseau-amylose.org\/jesuissoignant\/wp-content\/uploads\/sites\/5\/2025\/11\/score-pronostic-ATTR-reseau-amylose-1024x456.jpg\" class=\"attachment-large size-large wp-image-7329\" alt=\"score-pronostic-ATTR-re\u0301seau-amylose\" srcset=\"https:\/\/reseau-amylose.org\/jesuissoignant\/wp-content\/uploads\/sites\/5\/2025\/11\/score-pronostic-ATTR-reseau-amylose-1024x456.jpg 1024w, https:\/\/reseau-amylose.org\/jesuissoignant\/wp-content\/uploads\/sites\/5\/2025\/11\/score-pronostic-ATTR-reseau-amylose-300x133.jpg 300w, https:\/\/reseau-amylose.org\/jesuissoignant\/wp-content\/uploads\/sites\/5\/2025\/11\/score-pronostic-ATTR-reseau-amylose-768x342.jpg 768w, https:\/\/reseau-amylose.org\/jesuissoignant\/wp-content\/uploads\/sites\/5\/2025\/11\/score-pronostic-ATTR-reseau-amylose-1536x683.jpg 1536w, https:\/\/reseau-amylose.org\/jesuissoignant\/wp-content\/uploads\/sites\/5\/2025\/11\/score-pronostic-ATTR-reseau-amylose-2048x911.jpg 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8ec6efe elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8ec6efe\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3625933\" data-id=\"3625933\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bb0a749 elementor-widget elementor-widget-heading\" data-id=\"bb0a749\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">FAQ \u2014 Questions fr\u00e9quentes<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b33d6f6 elementor-widget elementor-widget-toggle\" data-id=\"b33d6f6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1871\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1871\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Quel score utiliser pour l'amylose AL ?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1871\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1871\"><p>Trois scores coexistent (Mayo 2004, Mayo 2012, European 2015), tous bas\u00e9s sur la troponine et le NT-proBNP\/BNP, avec ou sans cha\u00eenes l\u00e9g\u00e8res libres. Le choix d\u00e9pend des habitudes du centre et des biomarqueurs disponibles.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1872\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-1872\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Quelle diff\u00e9rence entre le score Mayo TTR et le score NAC ?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1872\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-1872\"><p>Le score Mayo TTR combine troponine et NT-proBNP ; le score NAC combine fonction r\u00e9nale (eGFR) et NT-proBNP. Les deux sont utilis\u00e9s dans l&rsquo;amylose \u00e0 transthyr\u00e9tine.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1873\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-1873\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Existe-t-il un score sp\u00e9cifique pour les patients d\u00e9j\u00e0 trait\u00e9s ?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1873\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-1873\"><p>Oui, un score publi\u00e9 en 2025 est valid\u00e9 chez les patients ATTRv d\u00e9j\u00e0 sous th\u00e9rapie sp\u00e9cifique (dont le tafamidis), combinant strain longitudinal global, NT-proBNP et fonction r\u00e9nale.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-975801f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"975801f\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-818c8a4\" data-id=\"818c8a4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ec06dad elementor-widget elementor-widget-text-editor\" data-id=\"ec06dad\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Plusieurs scores pronostiques indicatifs existent pour les amyloses, calcul\u00e9s \u00e0 partir des valeurs de biomarqueurs avant traitement. Pour l&rsquo;amylose AL, les scores Mayo 2004, Mayo 2012 et European 2015 combinent troponine, NT-proBNP\/BNP et parfois cha\u00eenes l\u00e9g\u00e8res libres. Pour l&rsquo;amylose \u00e0 transthyr\u00e9tine, le score Mayo TTR associe troponine et NT-proBNP, et le score NAC associe fonction r\u00e9nale et NT-proBNP. Un score plus r\u00e9cent (2025), sp\u00e9cifique aux patients ATTRv d\u00e9j\u00e0 trait\u00e9s par th\u00e9rapie cibl\u00e9e, combine strain longitudinal global, NT-proBNP et eGFR, avec des survies \u00e0 5 ans allant de 98,5 % (stade I) \u00e0 29,4 % (stade III). Ces outils, indicatifs, aident le clinicien \u00e0 estimer le pronostic et \u00e0 adapter le suivi.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6671bab elementor-widget elementor-widget-text-editor\" data-id=\"6671bab\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li class=\"font-claude-response-body whitespace-normal break-words pl-2\"><strong>R\u00e9dig\u00e9 par<\/strong> : Contenu r\u00e9dig\u00e9 par l&rsquo;\u00e9quipe du Centre de r\u00e9f\u00e9rence des Amyloses Cardiaques<\/li><li class=\"font-claude-response-body whitespace-normal break-words pl-2\"><strong>Relu \/ valid\u00e9 par<\/strong> : Pr Thibaud DAMY, cardiologue, Coordonateur du CRAC Centre de R\u00e9f\u00e9rence des Amyloses Cardiaques APHP &#8211; CHU Henri-Mondor<\/li><li class=\"font-claude-response-body whitespace-normal break-words pl-2\"><strong>Date de derni\u00e8re mise \u00e0 jour<\/strong> 08\/2026<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Evaluation du pronostic des amyloses : les scores Les scores pronostiques des amyloses estiment le pronostic du patient \u00e0 partir de biomarqueurs mesur\u00e9s avant traitement. Ils sont indicatifs et \u00e9voluent dans le temps. Des scores distincts existent pour l&rsquo;amylose AL et pour l&rsquo;amylose \u00e0 transthyr\u00e9tine (TTR). Points cl\u00e9s pour les professionnels de sant\u00e9 Les scores [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-2777","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Scores pronostiques de l&#039;amylose AL et TTR - R\u00e9seau Amylose<\/title>\n<meta name=\"description\" content=\"Mayo 2004, Mayo 2012, European 2015, NAC : les scores pronostiques de r\u00e9f\u00e9rence pour les amyloses AL et \u00e0 transthyr\u00e9tine.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/reseau-amylose.org\/jesuissoignant\/evaluation-du-pronostic-des-amyloses-les-scores\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Scores pronostiques de l&#039;amylose AL et TTR - 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